| Chemical |
Chromium(VI) oxide |
| CAS-number : |
1333-82-0 |
| |
| Synonyms : |
| chromic (VI)acid |
| Chromic acid |
| chromic anhydride |
| chromic trioxide |
| chromium (VI) oxide |
| chromium oxide |
| chromium trioxide |
| monochromium oxide |
| monochromium trioxide, kromihappo,kromitrioksidi. |
| |
| Sumformula of the chemical : |
| CrO3 |
| |
| Molecular weight : |
100 |
| |
| Water solubility, mg/l : |
| 617000 |
0°C |
| |
| Other information of bioaccumulation : |
Confirmed to be non-accumulative or low accumulative (Anon.
1987).
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 80 |
orl-rat, Sweet 1987 |
| 127 |
orl-mus |
| |
| LD50 values to mammals in non-oral exposure , mg/kg : |
| 29 |
ipr-mus, Lewis & Sweet 1984 |
| |
-- |
| 14 |
ipr-mus, Sweet 1987 |
| |
| LDLo values to mammals in non-oral exposure , mg/kg : |
| 330 |
scu-dog, Sweet 1987 |
| 20 |
scu-mus |
| |
| TDLo values to mammals in non-oral exposure , mg/kg : |
| 5 |
ivn-ham, 8 d preg. |
| |
specific developmental abnormalities |
| 7.5 |
ivn-ham, 8 d preg. |
| |
effects on fertility |
| |
effects on embryo of fetus |
| |
specific developmental abnormalities |
| 8 |
ivn-ham, 8 d preg. |
| |
specific developmental abnormalities |
| 20 |
scu-mus, 8 d preg. |
| |
effects on embryos or fetus |
| |
Sweet 1987 |
| |
-- |
| 125 |
implant-rat, tumorigenic, Sweet 1987 |
| |
| TCLo values to mammals in inhalation exposure, mg/kg : |
| 0.11 |
ihl, hmn, tumorigenic |
| |
Sweet 1987 |
| |
| Carcinogenicity : |
Inhalation: human TCLo 0.110 mg/m3/3Y-C; tumorigenic
(carcinogenic by RTECS criteria); sense organs and special
senses.
Implant: rat TDLo 125 mg/kg; tumorigenic (carcinogenic
by RTECS criteria); tumors at site of application.
|
| |
| Mutagenicity : |
Mutation data:
cyt, ham, emb, 0.068 mg/l;
cyt, ham, ovr, 0.250 mg/l;
cyt, ham, leu, 2 mg/l;
cyt, mus, mmr, 1 µmol/l, 48 hr;
dnd, esc, 5 mmol/l;
dnr, bsc, 50 mmol/l;
dnr, sat, 50 mmol/l;
microbial mutation without S9: esc, 8 µmol/l; sat, 1mmol/l;
mma, sat, 0.010 mg/plate;
sce, ham, ovr, 0.250 mg/l;
sce, ham, fbr, 0.320 mg/l (Sweet 1987).
|
| |
| LC50 values to fishes, mg/l : |
| 40 |
96 hr, Channa punctatus, Srivastava et. |
| |
al. 1979 |
References |
| 1848 | Anon. 1987a.
The list of the existing chemical substances tested
on biodegradability by microorganisms or bioaccumulation in
fish body by Chemicals Inspection & Testing Institute.
Ministry
of International Trade and Industry, MITI.
Japan. |
| 2285 | Anon. 1989.
Miljöfarliga ämnen - exempellista och vetenskaplig
dokumentation. 303 p.
Stockholm.
Rapport från
kemikalieinspektionen (KEMI) 10. |
| 1589 | Lewis, R.J. & Sweet, D.V. 1984.
Registry of toxic effects of
chemical substances.
National Institute for Occupational Safety
and Health.
No. 83-107-4. |
| 1362 | Srivastava, A.K. et al. 1979.
Effect of chromium on the
blood of a freshwater telost.
Ecotoxicol.
Environ.
Safety 3:
321. |
| 2101 | Sweet, D. 1987.
Registry of toxic effects of chemical
substances 1985 - 1986 edition.
U.S.
Department of health and
human services. |
