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Data bank of environmental chemicals     |     The Finnish Environment Institute (SYKE)
 


21.10.2019

Data bank of environmental properties of chemicals


Chemical
Acephate
CAS-number :
30560-19-1
 
Synonyms :
acetylphosphoramidothioic acid O,S-dimethyl ester
Asefaatti
O,S-dimethylacetylphosphoroamidothioate
Orthene.
Phosphoramidothioic acid, acetyl-, O,S-dimethyl ester
 
Sumformula of the chemical :
C4H10NO3PS
EINECS-number :
2502412
 
Molecular weight :
183.18
 
LD50 values to mammals in oral exposure, mg/kg :
321  orl-mam, Sweet 1987
233  orl-mus
700  orl-rat
 
LD50 values to mammals in non-oral exposure , mg/kg :
700  unk-rat, Virtanen & Nuuja 1987
351  unk-mus
380  unk-Peromyscus leucopus
321  unk-Microtus pennsylvanicus
  --
2000  skn-rbt, Sweet 1987
 
LDLo values to mammals in oral exposure, mg/kg :
681  orl-dog, Sweet 1987
 
LCLo values to mammals in inhalation exposure, mg/kg :
2200  5hr, ihl-mus, Sweet 1987
 
Mutagenicity :
unscheduled DNA synthesis:
human: fibroblast, 1000 mg/l;
gene conversion and mitotic recombination:
S. cerevisiae; 50000 ppm;
gene mutation in mammalian cells:
mouse, lymphocyte, 1000 mg/l;
microbial mutation without S9:
E.coli, 5 mg/plate; S. typhimurium, 3 mg/plate;
microsomal assay:
S. typhimurium, 50 mg/plate; S. cerevisiae, 3 pph;
sister chromatid exchange:
hamster, ovary, 2000 mg/l (Sweet 1987).
 
LD50 values to birds in oral exposure, mg/kg :
106  orl-domestic bird, Sweet 1987
852  orl-chicken
350  orl-dck
 
Effects on plants :
Increases in either fertilizer level or temperature resulted in
increased levels of phytotoxicity when plants were sprayed with
recommended rates (0.4 g/l) of acephate (Chase & Poole 1984).
 
LC50 values to crustaceans, mg/l :
7.3  srv, act, 96 hr, Mysidopsis bahia,
  Anon. 1981 (EPA 600/4-81-041)
3.8  srv, act, Penaeus duorarum, Anon. 1981
 
LC50 values to fishes, mg/l :
2740  srv, act, 96 hr, Salmo gaidneri, Geen et
  al. 1984
1880  srv, act, 25 hr, " "
  Duangsawasdi & Klaverkamp 1979
85  srv, act, 96 hr, Lagodon rhomboides,
  Anon. 1981
 
EC50 values to fishes, mg/l :
12600  phy, act, Salmo gairdneri, Watson et al.
  1984
 
Effects on physiology of water organisms :
Salmo gairdneri, 1 d, 100 - 400 mg/l, enzyme effect (Zinkl et al.
1987).

References
65Anon. 1981a. Miljövänlig tillverkning av blekt massa. Slutrapport. Svenska cellulosa- och pappersbrukförening. 182 s.
66Anon. 1981b. Wasserschadstoff-Katalog. Institut für wasserwirtschaft, Berlin. Januar 1981. Ab 652/63/81.
1799Chase, A.R. & Poole, R.T. 1984. Severity of acephate phytotoxicity on Spathiphyllum Schott. cv. Clevelandii as influenced by host nutrition and temperature, J. Am. Soc. Hortic. Sci. 109 (2): 168 - 172.
364Duangsawasdi, M. & Klaverkamp, J.F. 1979. Acephate and fenitrothion toxicity in rainbow trout: effects of temperature stress and investigations on the sites of action. In: Aquatic toxicology, ASTM STP 667. Marking,L.L. & Kimberle, R.A. (eds.)., 35, Amer. Soc. for Testing & Materials, Philadelphia, Pa.
470Geen, G.H., McKeown, B.A. & Oloffs, P.C. 1984. Acephate in rainbow trout (Salmo gairdneri): acute toxicity, uptake, elimination. J. Environ. Sci. Health B19: 131 - 155.
2102Pickering, Q., Carle, D.O., Pilli, A., Willingham, T. & Lazorchak, J.M. 1989. Effects of pollution on freshwater organisms. Journal WPCF 61 (6): 998 - 1042.
2101Sweet, D. 1987. Registry of toxic effects of chemical substances 1985 - 1986 edition. U.S. Department of health and human services.
1771Virtanen, M. & Nuuja, I. 1987. Kemikaalien myrkyllisyys luonnonvaraisille nisäkkäille. Ympäristöministeriö. Ympäristön- ja luonnonsuojeluosasto. Sarja D: 26.
1516Watson, T.A., Tilley, P.A.G., McKeown, B.A. & Geen, G.H. 1984. In vitro effects of acephate on acetylcholinesterase activity in the brain and gills of rainbow trout, Salmo gairdneri. J. Environ. Sci. Health, Part B: B19 ISS(2): 171 - 181.
2107Zinkl, J.G. et al. 1987. Effects of cholinesterases of rainbow trout exposed to Acephate and Methamidophos. Bull. Environ. Contam. Toxicol. 38: 22.

 
 
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