| Chemical |
Arsenic trioxide |
| CAS-number : |
1327-53-3 |
| |
| Synonyms : |
| Arseenitrioksidi |
| arsenious acid |
| arsenious oxide |
| arseniousanhydride. |
| |
| Sumformula of the chemical : |
| As2O3 |
| EINECS-number : |
| 2154814
|
| |
| Uses : |
Pigments, ceramic enamels, aniline colors, decolorizing agent in
glass, insecticide, rodenticide, herbicide, sheep and cattle dip,
hide preservative, wood preservative, preparation of other arsenic
compounds.
|
| |
| State and appearance : |
White powder.
|
| |
| Odor : |
Odourless, tasteless.
|
| |
| Molecular weight : |
197.84 |
| |
| Other physicochemical properties : |
Slightly soluble in water, soluble in acids and alkalies,
soluble in glycerol.
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 1.43 |
orl-man, Lewis & Sweet 1984 |
| 15.1 |
orl-rat, - " - |
| 39.4 |
orl-mus, - " - |
| |
-- |
| |
| LDLo values to mammals in oral exposure, mg/kg : |
| 10 |
orl-dog, Lewis & Sweet 1984 |
| |
| Other information of mammals : |
LDfr = 100 mg/kg/day, subacute, deer mouse (Virtanen & Nuuja
1987).
|
| |
| Carcinogenicity : |
Human carcinogen (Sax & Lewis 1987).
|
| |
| LD50 values to birds in oral exposure, mg/kg : |
| 13 |
orl-ckn, Lewis & Sweet 1984 |
| |
| Other information of birds : |
LDLo 13 mg/kg, idr-ckn, Lewis & Sweet 1984.
LDLo 100 mg/kg, idr-pgn, Lewis & Sweet 1984.
|
| |
| Effects on anthropods : |
LC50, 97.00 mg/l, 48hr, static, Tanytarsys dissimilis
(Holcombe et al. 1983).
|
| |
| LC50 values to crustaceans, mg/l : |
| 1 |
As, 7d, Daphnia magna |
| |
Spehar et al. 1980 |
| |
| LC50 values to fishes, mg/l : |
| 17 |
96 hr, Coregonus sp., Passino & Kramer |
| |
1980 |
| |
-- |
| 14.7 |
2d, Channa punctatus |
| 10.9 |
4d, Channa punctatus |
| |
Burton et al. 1987 |
| |
-- |
| 10.9 |
4d, Channa punctatus |
| |
Shukla et al. 1987 |
| |
-- |
| 18 |
48hr, Puntius |
| |
Pandey & Shukla 1979 |
| |
| Effects on physiology of water organisms : |
Channa punctatus; 5 mg/l, 13 days: growth effect (measurable
change in length and/or weight) (Burton et al. 1987).
Salmo gairdneri, 56 d, 200 µg/g, growth effect (Cockell &
Hilton 1988).
|
| |
| Other information of water organisms : |
LC50, 24.50 mg/l, 96hr, static, Aplexa hypnorum
(Holcombe et al. 1983).
|
| |
| Other information : |
Use of As2O3, worldwide:
wood preservative 16000 t/yr;
dehydrant for cotton 12000 t/yr;
herbicide 8000 t/yr;
raw material in medicines 5000 t/yr;
glass manufacturing 4000 t/yr;
metal alloys, chemicals in industry 5000 t/yr
------------------------------------------------
50000 t/yr
(Chilvers & Peterson 1987).
|
References |
| 1920 | Burton, G.A.
Jr., et al. 1987.
Arsenic toxicity changes in the
presence of sediment.
Bull.
Environ.
Contam.
Toxicol. 38: 491. |
| 2495 | Chilvers, D.C. & Peterson, P.J. 1987.
Global cycling of
arsenic.
In: Hutchinson, T.C. & Meerma, K.M.
(Eds.)
Lead,
mercury, cadmium and arsenic in the environment, SCOPE 31,
Wiley, New York, pp. 279 - 301. |
| 2120 | Cockell, K.A. & Hilton, J.W. 1988.
Preliminary investigations
on the comparative chronic toxicity of four dietary Arsenicals to
juvenile Rainbow trout (Salmo gairdneri R.).
Aquat.
Toxicol.
12: 73. |
| 594 | Holcombe, G.W., Phipps, G.L. & Fiandt, J.T. 1983.
Toxicity of
selected priority pollutants to various aquatic organisms.
Ecotoxicol.
Environ.
Saf. 8(2): 106 - 117. |
| 1589 | Lewis, R.J. & Sweet, D.V. 1984.
Registry of toxic effects of
chemical substances.
National Institute for Occupational Safety
and Health.
No. 83-107-4. |
| 1101 | Pandey, K. & Shukla, J.P. 1979.
Arsenic toxicity in a tropical
freshwater fish, Puntilis sophore.
Nat.
Acad.
Sci.
Letters 2:
425. |
| 1110 | Passino, D.R.M. & Kramer, J.M. 1980.
Toxicity of arsenic
and PCBs to fry of deepwater Ciscoes (Coregonus).
Bull.
Environ.
Contam.
Toxicol. 24: 527. |
| 2102 | Pickering, Q., Carle, D.O., Pilli, A., Willingham, T. &
Lazorchak, J.M. 1989.
Effects of pollution on freshwater
organisms.
Journal WPCF 61 (6): 998 - 1042. |
| 2522 | Sax, N.I. & Lewis, R.J.Sr. 1987.
Hawley's condensed chemical
dictionary.
Eleventh edition.
Van Nostrand Reinhold Company.
New York. pp. 1288. |
| 2126 | Shukla, J.P. et al. 1987.
Survivality and impaired growth in
arsenic treated fingerlings of Channa punctatus, a freshwater
murrel.
Acta Hydrochim.
Hydrobiol. 15: 307. |
| 2502 | Spehar, R.L., Fiandt, J.T., Anderson, R.L. & DeFoe, D.L. 1980.
Arch.
Environ.
Contam.
Toxicol. 9: 53 - 63. |
| 1771 | Virtanen, M. & Nuuja, I. 1987.
Kemikaalien myrkyllisyys
luonnonvaraisille nisäkkäille.
Ympäristöministeriö.
Ympäristön-
ja luonnonsuojeluosasto.
Sarja D: 26. |
| 2494 | WHO 1981.
Arsenic.
Environmental Health Criteria, Vol. 18.
World Health Organization, Geneva. |
