Chemical |
3-Methylindole |
CAS-number : |
83-34-1 |
|
Synonyms : |
1H-Indole, 3-methyl- |
beta-methylindole |
|
Sumformula of the chemical : |
C9H9N |
EINECS-number : |
2014717 |
|
Melting point, °C : |
95 |
Richardson et al. 1994 |
|
Boiling point, °C : |
265 |
265-266°C, Richardson et al. 1994 |
266 |
|
|
Log octanol/water coefficient, log Pow : |
2.6 |
Richardson et al. 1994 |
|
Other physicochemical properties : |
Soluble in hot water.
Organic solvent: ethanol, chloroform,
diethyl ether and benzene (Richardson et al. 1994).
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|
Other information of degradation : |
Nitrification inhibition: at 7 mg/l 75% inhibition of ammonia
oxidation (activated sludge) (Rickhardson et al. 1994).
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|
Metabolism in mammals : |
It requires activation by cytochrome P450 to be cytotoxic in
rabbit pulmonary cells (Richardson et al. 1994).
|
|
LD50 values to mammals in oral exposure, mg/kg : |
3450 |
orl-rat, RTECS 1996 |
|
-- |
3450 |
orl-rat, Richardson et al. 1994 |
|
LD50 values to mammals in non-oral exposure , mg/kg : |
175 |
ipr-mus, RTECS 1996 |
|
-- |
175 |
ipr-mus, Richardson et al. 1994 |
|
LDLo values to mammals in oral exposure, mg/kg : |
470 |
orl-mus |
200 |
orl-cattle, Richardson et al. 1994 |
|
LDLo values to mammals in non-oral exposure , mg/kg : |
60 |
ivn-cattle, Richardson et al. 1994 |
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Effects on physiology of mammals : |
Intraperitoneal (28 day) mice 400 mg/kg, cellular swelling was
apparent in the olfactory epithelium by 6 hr.
Necrosis of the
olfactory epithelium and subepithelial glands were diffuse by
48 hr.
Subsequent ulceration resulted in epithelial
hyperplasia, squamous metaplasia, fibroplasia and ossification
(Turk et al. 1987).
Infusion (72 hr) goats 35 mg/kg body weight, prostaglandin
concentrations in lungs were unaffected.
Plasma and lung
prostaglandin and thromboxane B2 concentrations did not appear
to be altered in 3-methylindole-induced lung disease (Acton et
al. 1989).
A dose of 550 mg/kg specifically damaged pulmonary tissue in
Swiss-Webster mice witout causing any hepatic or renal
necrosis.
When a glutathione depleter was administered to mice
3 hr before low dose of 3-methylindene (75 mg/kg),
histopatological examination after 4 hr showed renal damage.
The production of a toxic metabolite in the livers of
gluthahione -depleted mice that is circulated to susceptible
renal cells may be the mechanism of this toxicity (Yost et al.
1990).
The electrophilic imine methide may be the intermediate which
binds with and depletes glutathione.
An imine methide is the
primery reactive intermediate in 3-methylindole mediated
pneumotoxicity (Huijzer et al. 1987).
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|
Mutagenicity : |
Salmonella typhimurium TA100 without metabolic activation,
strong mutagenic activity (Richardson et al. 1994).
|
|
LC50 values to fishes, mg/l : |
8.84 |
96 hr, Pimephales promelas, Geiger et al. 1990 |
|
EC50 values to fishes, mg/l : |
5.45 |
<5.45 mg/kg, 96 hr, mbt, Pimephales promelas, |
|
Geiger et al. 1990 |
References |
3309 | Acton, K.
S. et al. 1989.
Comp.
Biochem.
Physiol., A : Comp.
Physiol. 94A(4), 677 - 681.
|
3297 | Geiger, D.
L. et al. 1990.
Acute toxicities of organic
chemicals to fathead minnows (Pimephales promelas) Vol 5.
Center for Lake Superior Environmental Studies, University of
Winsconsin-Superior, Superior, Winconsin, U.S.A. 332.
|
3311 | Huijzer, J.
C. et al. 1987.
Toxicol.
Appl.
Pharmacol. 90(1), 60
- 68.
|
3298 | Richardson, M.
L. et al. 1992 - 1994.
The dictionary of
substances and their effects.
Vol 1 - 7.
The Royal Society of
Chemistry.
Thomas Graham House, The Science Park, Cambridge,
CB4 4WF.
|
3115 | RTECS Database 1992 -.
Registry of Toxic Effects of Chemical
Substances.
National Institute of Occupational Safety and
Health, USA.
TOMES Plus CD-ROM.
|
3308 | Turk, M.
A.
M. et al. 1987.
Vet.
Pathol. 24(5), 400 - 403.
|
3310 | Yost, G.
S. et al. 1990.
Toxicol.
Appl.
Pharmacol. 103(1), 40 -
51.
|