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Data bank of environmental chemicals     |     The Finnish Environment Institute (SYKE)
 


29.3.2024

Data bank of environmental properties of chemicals


Chemical
p-Vanillin
CAS-number :
121-33-5
 
Synonyms :
3-Methoxy-4-hydroxybenzaldehyde
Benzaldehyde, 4-hydroxy-3-methoxy-
Bioxin
m-Anisaldehyde, 4-hydroxy-
Methyl protocatechui aldehyde
p-Hydroxy-m-methoxybenzaldehyde
Protocatechualdehyde, methyl-
Vanillaldehyde
Vanillap-vanillin
Vanillic aldehyde
 
Sumformula of the chemical :
C8H8O3
EINECS-number :
2044652
 
Uses :
Organic synthesis. 
In deodorants. 
Falvou agent in confectionary 
and cosmetics. 
Analytical reagent. 
Insect attractant.
 
Spesicif gravity (water=1) :
1.056  Richardson et al. 1994
 
Vapor density (air=1) :
5.2  Richardson et al. 1994
 
Vapor pressure, mmHg :
1mm HG at 107°C, Richardson et al. 1994
 
Melting point, °C :
81  81-83°C, Richardson et al. 1994
83 
 
Boiling point, °C :
285  Richardson et al. 1994
 
Log octanol/water coefficient, log Pow :
1.26  Richardson et al. 1994
 
Other physicochemical properties :
Soluble in water 1% at 20°C. 
Organic solvent: acetone, 
chloroform, ethanol and diethyl ether (Richardson et al. 1994).
 
Other information of degradation :
Utilised as dole carbon source by Bacillus subtilis (Richardson 
et al. 1994).
 
Metabolism in mammals :
Urinary metabolites identified following intraperitoneal 
administration to rats are pricipally vanillic acid (both free 
and conjugated), conjugated vanillin and vanillyl alcohol and 
catechol (Richardson et al. 1994).
 
LD50 values to mammals in oral exposure, mg/kg :
1580  orl-rat
4330  orl-mus
1400  orl-gpg, RTECS 1996
  --
1400  1400-1600 mg/kg, orl-rat and gpg,
1600  Richardson et al. 1994
 
LD50 values to mammals in non-oral exposure , mg/kg :
1160  ipr-rat
1500  scu-rat
475  ipr-mus, RTECS 1996
  --
1500  scu-rat
480  irp-rat
1200  ipr-mus
1160  ipr-gpg, Richardson et al. 1994
 
Health effects :
Positive in patch tests 8/142 sensitised subjects (Richardson 
et al. 1994).
 
Carcinogenicity :
Oral rat (2 yr) 5000, 10 000 and 20 000 ppm diet caused no 
adverse effects (Richardson et al. 1994).
 
Mutagenicity :
Salmonella typhimurium TA98, TA100, TA1535, TA1538 with and 
without metabolic activation negative.

In vitro human lymphocytes sister chromatid exchanges positive 
(Richardson et al. 1994).
 
Teratogenicity :
Subcutaneous female rat, lowest dose 20 mg/kg 4 days prior 
mating - effects to ovaries, fallotoppian tube, uterus and 
cervix (Richardson et al. 1994).
 
LC50 values to fishes, mg/l :
57  96 hr, Pimephales promelas
123  96 hr, Pimephales promelas, Brooke et al. 1984
  --
120  96 hr, Pimepohales promelas, static bioassay,
  Richardson et al. 1994
 
EC50 values to fishes, mg/l :
57  96 hr, bhv, Pimephales promelas
123  96 hr, bhv, Pimephales promelas, Brooke et al. 1984

References
3295Brooke, L. T. et al. 1984. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas); Vol 1. Center for Lake Superior Environmental Studies University of Wisconsin-Superior, Superior, Wisconsin, U.S.A.
3298Richardson, M. L. et al. 1992 - 1994. The dictionary of substances and their effects. Vol 1 - 7. The Royal Society of Chemistry. Thomas Graham House, The Science Park, Cambridge, CB4 4WF.
3115RTECS Database 1992 -. Registry of Toxic Effects of Chemical Substances. National Institute of Occupational Safety and Health, USA. TOMES Plus CD-ROM.

 
 
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