Chemical |
p-Vanillin |
CAS-number : |
121-33-5 |
|
Synonyms : |
3-Methoxy-4-hydroxybenzaldehyde |
Benzaldehyde, 4-hydroxy-3-methoxy- |
Bioxin |
m-Anisaldehyde, 4-hydroxy- |
Methyl protocatechui aldehyde |
p-Hydroxy-m-methoxybenzaldehyde |
Protocatechualdehyde, methyl- |
Vanillaldehyde |
Vanillap-vanillin |
Vanillic aldehyde |
|
Sumformula of the chemical : |
C8H8O3 |
EINECS-number : |
2044652 |
|
Uses : |
Organic synthesis.
In deodorants.
Falvou agent in confectionary
and cosmetics.
Analytical reagent.
Insect attractant.
|
|
Spesicif gravity (water=1) : |
1.056 |
Richardson et al. 1994 |
|
Vapor density (air=1) : |
5.2 |
Richardson et al. 1994 |
|
Vapor pressure, mmHg : |
1 |
1mm HG at 107°C, Richardson et al. 1994 |
|
Melting point, °C : |
81 |
81-83°C, Richardson et al. 1994 |
83 |
|
|
Boiling point, °C : |
285 |
Richardson et al. 1994 |
|
Log octanol/water coefficient, log Pow : |
1.26 |
Richardson et al. 1994 |
|
Other physicochemical properties : |
Soluble in water 1% at 20°C.
Organic solvent: acetone,
chloroform, ethanol and diethyl ether (Richardson et al. 1994).
|
|
Other information of degradation : |
Utilised as dole carbon source by Bacillus subtilis (Richardson
et al. 1994).
|
|
Metabolism in mammals : |
Urinary metabolites identified following intraperitoneal
administration to rats are pricipally vanillic acid (both free
and conjugated), conjugated vanillin and vanillyl alcohol and
catechol (Richardson et al. 1994).
|
|
LD50 values to mammals in oral exposure, mg/kg : |
1580 |
orl-rat |
4330 |
orl-mus |
1400 |
orl-gpg, RTECS 1996 |
|
-- |
1400 |
1400-1600 mg/kg, orl-rat and gpg, |
1600 |
Richardson et al. 1994 |
|
LD50 values to mammals in non-oral exposure , mg/kg : |
1160 |
ipr-rat |
1500 |
scu-rat |
475 |
ipr-mus, RTECS 1996 |
|
-- |
1500 |
scu-rat |
480 |
irp-rat |
1200 |
ipr-mus |
1160 |
ipr-gpg, Richardson et al. 1994 |
|
Health effects : |
Positive in patch tests 8/142 sensitised subjects (Richardson
et al. 1994).
|
|
Carcinogenicity : |
Oral rat (2 yr) 5000, 10 000 and 20 000 ppm diet caused no
adverse effects (Richardson et al. 1994).
|
|
Mutagenicity : |
Salmonella typhimurium TA98, TA100, TA1535, TA1538 with and
without metabolic activation negative.
In vitro human lymphocytes sister chromatid exchanges positive
(Richardson et al. 1994).
|
|
Teratogenicity : |
Subcutaneous female rat, lowest dose 20 mg/kg 4 days prior
mating - effects to ovaries, fallotoppian tube, uterus and
cervix (Richardson et al. 1994).
|
|
LC50 values to fishes, mg/l : |
57 |
96 hr, Pimephales promelas |
123 |
96 hr, Pimephales promelas, Brooke et al. 1984 |
|
-- |
120 |
96 hr, Pimepohales promelas, static bioassay, |
|
Richardson et al. 1994 |
|
EC50 values to fishes, mg/l : |
57 |
96 hr, bhv, Pimephales promelas |
123 |
96 hr, bhv, Pimephales promelas, Brooke et al. 1984 |
References |
3295 | Brooke, L.
T. et al. 1984.
Acute toxicities of organic
chemicals to fathead minnows (Pimephales promelas); Vol 1.
Center for Lake Superior Environmental Studies University of
Wisconsin-Superior, Superior, Wisconsin, U.S.A.
|
3298 | Richardson, M.
L. et al. 1992 - 1994.
The dictionary of
substances and their effects.
Vol 1 - 7.
The Royal Society of
Chemistry.
Thomas Graham House, The Science Park, Cambridge,
CB4 4WF.
|
3115 | RTECS Database 1992 -.
Registry of Toxic Effects of Chemical
Substances.
National Institute of Occupational Safety and
Health, USA.
TOMES Plus CD-ROM.
|