| Chemical |
1-Chloro-2-propanol |
| CAS-number : |
127-00-4 |
| |
| Synonyms : |
| 1-chloro-2-hydroxypropane |
| 1-chloroisopropyl alcohol |
| 2-chloropropyl alcohol |
| 2-Propanol, 1-chloro- |
| alpha-Propylene chlorohydrin |
| sec-propylene chlorohydrin |
| |
| Sumformula of the chemical : |
| C3H7ClO |
| EINECS-number : |
| 2048196 |
| |
| Uses : |
In the preparation of propylene oxide.
Intermediate in organic
synthesis.
|
| |
| Spesicif gravity (water=1) : |
| 1.111 |
Richardson et al. 1993 |
| |
| Vapor pressure, mmHg : |
| 4.9 |
Richardson et al. 1993 |
| |
| Boiling point, °C : |
| 133 |
133-134, Richardson et al. 1993 |
| 134 |
|
| |
| Flashing point, °C : |
| 51.7 |
Richardson et al. 1993 |
| |
| Other physicochemical properties : |
Miscible in water.
Soluble in organic solvents: diethyl ether,
ethanol, dimethyl sulfoxide (Richardson et al. 1993).
|
| |
| Metabolism in mammals : |
Urinary excretion and exhalation as carbon dioxide accounted
for 80% of total intraperitoneal dose in rats.
Major urinary metabolite detected
N-acetyl-S-(2-hydroxypropyl)cysteine, with minor metabolite
beta-chlorolactate and N-acetyl-S-(2,3-dihydroxypropyl)cysteine
In rats after exposure by in halation excreted via lungs as
carbon dioxide.
Metabolised via cysteine conjugates and
mercapturic acids excreted in urine (Richardson et al. 1993).
|
| |
| LC50 values to mammals in inhalation exposure, ppm : |
| 1000 |
4 hr, rat, Richardson et al. 1993 |
| |
| Health effects : |
Reported to cause skin irritation.
Vapour or mist irritating to
eyes, mucous membranes and upper respiratory tract (Richardson
et al. 1993).
|
| |
| Carcinogenicity : |
2 yr study in rats and mice administered via drinking water in
progress (Richardson et al. 1993).
|
| |
| Mutagenicity : |
Salmonella typhimurium TA98, TA100, TA1535, TA1737 with and
without (?) metabolic activation positive.
Salmonella typhimurium TA1530 with and without metabolic
activetion positive (Richardson et al. 1993).
|
| |
| Teratogenicity : |
Technical grade 1-chloro-2-propanol (75-76%) admistered rats
via drinking water.
In 14 day dose-finding study 0.2-0.8%
adversely affected weight gain and drinking.
In continuous
breeding protocol it had no effect on fertility or reproduction
(little size, number and days to deliver) in F0 and F1
generation.
May adversely affect sperm morphology (Richardson
et al. 1993).
|
| |
| LC50 values to fishes, mg/l : |
| 245 |
96 hr, Pimephales promelas, Brooke et al. 1984 |
| |
| EC50 values to fishes, mg/l : |
| 217 |
96 hr, bhv, Pimephales promelas, Brooke et al. 1984 |
References |
| 3295 | Brooke, L.
T. et al. 1984.
Acute toxicities of organic
chemicals to fathead minnows (Pimephales promelas); Vol 1.
Center for Lake Superior Environmental Studies University of
Wisconsin-Superior, Superior, Wisconsin, U.S.A.
|
| 3298 | Richardson, M.
L. et al. 1992 - 1994.
The dictionary of
substances and their effects.
Vol 1 - 7.
The Royal Society of
Chemistry.
Thomas Graham House, The Science Park, Cambridge,
CB4 4WF.
|
| 3115 | RTECS Database 1992 -.
Registry of Toxic Effects of Chemical
Substances.
National Institute of Occupational Safety and
Health, USA.
TOMES Plus CD-ROM.
|
