| Chemical |
Ethylaniline |
| CAS-number : |
589-16-2 |
| |
| Synonyms : |
| 1-Amino-4-ethylbenzene |
| Benzenamine, 4-ethyl- |
| p-ethylaminobenzene |
| p-Ethylaniline |
| |
| Sumformula of the chemical : |
| C8H11N |
| EINECS-number : |
| 2096370 |
| |
| Uses : |
Chemical intermediate in the manufacture of pharmaceuticals,
dyestuffs and pesticides.
|
| |
| Spesicif gravity (water=1) : |
| 0.975 |
Richardson et al. 1994 |
| |
| Melting point, °C : |
| -5 |
Richardson et al. 1994 |
| |
| Boiling point, °C : |
| 216 |
Richardson et al. 1994 |
| |
| Flashing point, °C : |
| 85 |
Richardson et al. 1994 |
| |
| Log octanol/water coefficient, log Pow : |
| 1.96 |
Richardson et al. 1994 |
| |
| Other physicochemical properties : |
Slightly soluble in water.
Organic solvents: ethanol, toluene,
carbontetrachloride (Richardson et al. 1994).
|
| |
| Metabolism in mammals : |
Salmonella typhimurium TA98, TA100, TA1535, TA1537, G46,C3076,
D3052 with and without metabolic activation negative.
Esherichia coli WP2, WP2 uvrA- with and without metabolic
activation negative.
In vitro primary rat hepatocytes, unscheduled DNA synthesis
positive (Thompson et al. 1983).
In vitro Balb/3T3 cells, aniline derivatives showed significant
liver metabolism-mediated changes in cytotoxicity when
cocultivative with primary rat liver cells.
No direct
interaction of nucleosides observed following in vitro reaction
with aniline derivatives (Harada 1990).
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 500 |
orl-mus |
| 422 |
orl-qal, RTECS 1996 |
| |
-- |
| 75 |
75-750 mg/kg, orl-mus, Richardson et al. 1994 |
| 750 |
|
| |
| LD50 values to mammals in non-oral exposure , mg/kg : |
| 133 |
ips-mus |
| 56 |
ivn-mus, RTECS 1996 |
| |
-- |
| 133 |
ipr-mus |
| 56 |
ivn-mus, Richardson et al. 1994 |
| |
| Effects on physiology of mammals : |
Abdorption into the body leads to the formation of
methaemoglobin which in sufficient concentrations causes
cyanosis (Richardson et al. 1994).
|
| |
| Health effects : |
Irritating to eyes, skin, mucous membranes and upper
respiratory tract (species unspecified) (Richardson et al.
1994).
|
| |
| LD50 values to birds in oral exposure, mg/kg : |
| 75 |
75-750 mg/kg, Turdus merula |
| 750 |
|
| 75 |
75-750 mg/kg, Coturnix |
| 750 |
|
| 75 |
75-750 mg/kg, Sturnus vulgaris |
| 750 |
Richardson et al. 1994 |
| |
| Effects on microorganisms : |
EC 50 (30min) 0.211 ppm Photobacterium phosphoreum, Microtox
test.
EC50 (48hr) 110 mg/l Tetrahymena pyriformis (Richardson et al.
1994).
|
| |
| EC50 values to crustaceans, mg/l : |
| 2 |
48 hr, Daphnia magna |
| 19 |
24 hr, Daphnia magna, Richardson et al. 1994 |
| |
| LC50 values to fishes, mg/l : |
| 73 |
96 hr, Pimephales promelas, Geiger et al. 1986 |
| |
-- |
| 29 |
14 d, Lebistes reticulatus, Richardson et al. 1994 |
| |
| EC50 values to fishes, mg/l : |
| 73 |
96 hr, mbt, Pimephales promelas, Geiger et al. 1986 |
References |
| 3294 | Geiger, D.
L. et al. 1986.
Acute toxicities of organic
chemicals to fathead minnows (Pimephales promelas) Vol. 3.
Center for Lake Superior Environmental Studies, University of
Wisconsin-Superior, Superior, Wisconsin, U.S.A., 328.
|
| 3306 | Harada, A. 1990.
Kanazawa Daigaku Juzen Igakkai Zasshi. 99(1),
233 - 247 (Japan) (Chem.
Abstr. 144,37308e).
|
| 3298 | Richardson, M.
L. et al. 1992 - 1994.
The dictionary of
substances and their effects.
Vol 1 - 7.
The Royal Society of
Chemistry.
Thomas Graham House, The Science Park, Cambridge,
CB4 4WF.
|
| 3115 | RTECS Database 1992 -.
Registry of Toxic Effects of Chemical
Substances.
National Institute of Occupational Safety and
Health, USA.
TOMES Plus CD-ROM.
|
| 3305 | Thompson, C.
Z. et al. 1983.
Environ.
Mutagen. 5(6), 803 - 811.
|
