| Chemical |
4-nitroaniline |
| CAS-number : |
100-01-6 |
| |
| Synonyms : |
| 1-amino-4-nitrobenzene |
| 4-aminonitrobenzene. |
| 4-nitroaniliini |
| p-nitroaniline |
| |
| Sumformula of the chemical : |
| C6H6N2O2 |
| EINECS-number : |
| 2028101 |
| |
| Uses : |
intermediate for dyes and antioxidants, gasoline gum inhibitors,
medicinals for poultry, corrosion inhibitor
|
| |
| State and appearance : |
yellow monoclinic needles
|
| |
| Molecular weight : |
138.14 |
| |
| Vapor pressure, mmHg : |
| 0.0015 |
20°C |
| |
| Water solubility, mg/l : |
| 800 |
19°C |
| |
| Melting point, °C : |
| 147.5 |
|
| 148.5 |
148.5 - 150, MITI 1992 |
| |
| Boiling point, °C : |
| 260 |
260/332, decomposes |
| 332 |
|
| |
| Log octanol/water coefficient, log Pow : |
| 2.66 |
Anon 1988 |
| |
| Log soil sorption coefficient, log Kom : |
| 1.64 |
Sabljic 1987 |
| |
| Henry's law constant, Pa x m3/mol : |
| 0.035 |
Anon 1988 |
| |
| Mobility : |
Equilibrium distribution:
mass %
air 1.10
water 92.42
solid 6.49
(Anon 1988)
|
| |
| Total degradation in soil : |
Biodegradation: decomposition by a soil microflora in > 64 days
(Verschueren 1983).
|
| |
| Total degradation in water : |
Biodegradation:
0% by BOD
period: 14d
substance: 100 mg/l
sludge: 30 mg/l
(MITI 1992)
|
| |
| Ready biodegradability : |
Confirmed to be non-biodegradable (Anon. 1987). |
| |
| Bioconcentration factor, fishes : |
| 2.9 |
2.9 - 3.6, 6w, Cyprinus caarpio, conc 0.5 mg/l, |
| 3.6 |
|
| 10 |
< 10, 6w, Cyprinus carpio, conc 0.05 mg/l, |
| |
| Other information of bioaccumulation : |
Confirmed to be non-accumulative or low accumulative (Anon.
1987).
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 750 |
orl-rat, Lewis & Sweet 1984 |
| 450 |
orl-gpg, - " - |
| |
| LD50 values to birds in oral exposure, mg/kg : |
| 75 |
orl-bwd, Lewis & Sweet 1984 |
| |
-- |
| 75 |
75.0 - 100, orl-Agelaius phoeniceus |
| 100 |
|
| 1000 |
>1000, orl-Sturnus vulgaris |
| 1000 |
orl-Coturnix coturnix |
| |
Schafer et al. 1983 |
| |
| Effects on microorganisms : |
Toxicity threshold (cell multiplication inhibition test):
bacteria (Pseudomonas putida): 4 mg/l
(Bringmann & Kühn 1980a)
|
| |
| LOEC values to algae, mg/l : |
| 0.35 |
rpd, schr, Microcystis aeruginosa |
| |
Bringmann & Kühn 1976 |
| |
| LC50 values to fishes, mg/l : |
| 35 |
48 hr, Leuciscus idus, Wellens 1982 |
| 87.6 |
96 hr, Branchydanio rerio |
| |
-- |
| 106 |
96 hr, Pimephales promelas |
| |
Curtis & Ward 1981 |
| |
-- |
| 84 |
48hr, Oryzias latipes, MITI 1992 |
| |
-- |
| 125 |
96 hr, Pimephales promelas, Geiger et al. 1990 |
| |
| EC50 values to fishes, mg/l : |
| 96.9 |
96 hr, mbt, Pimephales promelas, Geiger et al. 1990 |
| |
| Other information of water organisms : |
LOEC 3.1 mg/l, rpd, schr, Uronema parduczi (Bringmann & Kühn
1980b).
EC50 (60hr), 10 mg/l, rpd, Tetrahymena pyriformis (Schultz &
Applehans 1985).
Toxicity threshold (cell multiplication inhibition test):
green algae (Scenedesmus quadricauda): 11 mg/l
protozoa (Entosiphon sulcatum): 6.9 mg/l
(Bringmann & Kühn 1980a)
|
References |
| 2357 | Anon 1988.
Concentrations of industrial organic chemicals
measured in the environment: The influence of physico - chemical
properties, tonnage and use pattern.
Technical report no 29.
European chemical industry ecology & toxicology centre, ECETOC.
pp. 105. |
| 1848 | Anon. 1987a.
The list of the existing chemical substances tested
on biodegradability by microorganisms or bioaccumulation in
fish body by Chemicals Inspection & Testing Institute.
Ministry
of International Trade and Industry, MITI.
Japan. |
| 187 | Bringmann, G. & Kühn, R. 1976.
Vergleichende Befunde der
Schadwirkung wassergefährdender Stoffe gegen Bakterien
(Pseudomonas putida) und Blaualgen (Microcystis aeruginosa).
Gwf-Wasser-Abwasser 117(9). |
| 188 | Bringmann, G. & Kühn, R. 1980a.
Comparison of the toxicity
thresholds of water pollutants to bacteria, algae and
protozoa in the cell multiplication inhibition test.
Water
Res. 14: 231 - 241. |
| 189 | Bringmann, G. & Kühn, R. 1980b.
Bestimmung der biologischen
Schadwirkung wassergefahrdender Stoffe gegen Protozoen.
II.
Bakterienfressende Ciliaten, Z.
Wasser/Abwasser Forsch. 1: 26 -
31. |
| 299 | Curtis, M.W. & Ward, C.H. 1981.
Aquatic toxicity of 40
industrial chemicals.
Testing in support of hazardous
substance spill prevention regulation.
J.
Hydrol. 51: 359. |
| 3297 | Geiger, D.
L. et al. 1990.
Acute toxicities of organic
chemicals to fathead minnows (Pimephales promelas) Vol 5.
Center for Lake Superior Environmental Studies, University of
Winsconsin-Superior, Superior, Winconsin, U.S.A. 332.
|
| 1589 | Lewis, R.J. & Sweet, D.V. 1984.
Registry of toxic effects of
chemical substances.
National Institute for Occupational Safety
and Health.
No. 83-107-4. |
| 3105 | MITI 1992.
Biodegradation and bioaccumulation data of existing
chemicals based on the CSCL Japan.
Compild under the Safety
Division Basic Industries Bureau Ministry of International
Trade & Industry, Japan.
Edited by Chemicals Inspection &
Testing Institute, Japan.
|
| 2324 | Sabljic, A. 1987.
On the prediction of soil sorption
coefficients of organic pollutants from molecular structure:
application of molecular topology model.
Environ.
Sci.
Technol.
21: 358 - 366. |
| 1743 | Schafer , E.W.Jr., Bowles, W.A.Jr., Hurlbut, J. 1983.
The acute
oral toxicity, repellency and hazard potential of 993 chemicals to
one or more species of wild and domestic birds.
Arch.
Environ.
Contam.
Toxicol. 12: 355 - 382. |
| 1248 | Shultz, T.W. & Applehans, F.M. 1985.
Correlations for the acute
toxicity of multiple nitrogen substituted aromatic molecules.
Ecotox.
Environm.
Safety 10: 75 - 85. |
| 1531 | Wellens, H. 1982.
Comparison of the sensitivity of
Branchydanio rerio and Leucistus idus by testing the fish
toxicity of chemicals and wastewaters.
Z.
Wasser Abwasser
Forsch.
(Ger.) 15: 49. |
