| Chemical |
Acetylsalicylic acid |
| CAS-number : |
|
| |
| Synonyms : |
| 2-acetoxybenzoic acid |
| asetyylisalisyylihappo. |
| aspirin |
| o-carboxyphenyl acetate |
| Salicylic acid, acetate |
| |
| Molecular weight : |
180.17 |
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 1075 |
orl-gpg, Sweet 1987 |
| 3500 |
orl-ham, Sweet 1987 |
| 1750 |
orl-mam, Sweet 1987 |
| 250 |
orl-mus, Sweet 1987 |
| 200 |
orl-rat, Sweet 1987 |
| 1010 |
orl-rbt, Sweet 1987 |
| |
| LD50 values to mammals in non-oral exposure , mg/kg : |
| 280 |
ipr-mus, Sweet 1987 |
| 390 |
ipr-rat, Sweet 1987 |
| 681 |
ivn-dog, Sweet 1987 |
| 790 |
rec-rat, Sweet 1987 |
| 1020 |
scu-mus, Sweet 1987 |
| |
| LDLo values to mammals in oral exposure, mg/kg : |
| 104 |
orl-chd, Sweet 1987 |
| 500 |
orl-dog, Sweet 1987 |
| |
| TDLo values to mammals in oral exposure, mg/kg : |
| 300 |
orl-cat, 10 - 15 d preg |
| |
effects on embryo or fetus |
| 3200 |
orl-dog, 23 - 30 d preg |
| |
specific developmental abnormalities |
| 1200 |
orl-mus, 8 - 9 d preg |
| |
effects on fertility |
| 2500 |
orl-mus, 6 - 15 d preg |
| |
effects on embryo or fetus |
| 500 |
orl-rat, 9d preg, effects on embryo or |
| |
fetus |
| 10 |
orl-rat, 22d preg, maternal effects |
| 1800 |
orl-rbt, 8 - 16 d preg |
| |
specific developmental abnormalities |
| 600 |
orl-rbt, 2d preg, effects on ferlity |
| 100 |
orl-wmn, 37 w preg, effects on newborn |
| |
Sweet 1987 |
| |
-- |
| 669 |
orl-hmn, Sweet 1987 |
| 120 |
orl-inf, Sweet 1987 |
| |
| TDLo values to mammals in non-oral exposure , mg/kg : |
| 500 |
scu-mus, 11d, effects on fertility |
| 380 |
scu-rat, 9d, effects on fertility |
| 500 |
scu-rat, 11d, specific developmental |
| |
Sweet 1987 |
| |
| Mutagenicity : |
cyt, ham, lug, 1660 mg/l;
cyt, hmn, fbr, 100 mg/l;
cyt, hmn, leu, 0.1 mg/l;
cyt, hmn, lym, 10 mg/l;
otr, rat, emb, 0.108 mg/l;
test systems, hmn, lym, 75 mg/l.
(Sweet 1987)
|
References |
| 2101 | Sweet, D. 1987.
Registry of toxic effects of chemical
substances 1985 - 1986 edition.
U.S.
Department of health and
human services. |
