| Chemical |
Endrin |
| CAS-number : |
72-20-8 |
| |
| Synonyms : |
| 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydroexo-1,4-exo-1,4-exo-5,8-dimethanonaphthalene |
| endriini |
| |
| Sumformula of the chemical : |
| C12H8Cl6O |
| EINECS-number : |
| 2007757 |
| |
| Uses : |
insecticide, rodenticide
|
| |
| Molecular weight : |
380.9 |
| |
| Vapor pressure, mmHg : |
| 0.0000002 |
25°C |
| |
| Water solubility, mg/l : |
| 0.18 |
MITI 1992 |
| |
| Melting point, °C : |
| 200 |
approx. 200 |
| 245 |
MITI 1992 |
| |
| Log octanol/water coefficient, log Pow : |
| 5.63 |
Anon 1988 |
| 4.56 |
Mackay 1982 |
| 5.22 |
MITI 1992 |
| |
| Henry's law constant, Pa x m3/mol : |
| 0.1 |
Anon 1988 |
| |
| Mobility : |
Equilibrium distribution:
mass %
air 0.05
water 1.50
solid 98.44
(Anon 1988)
|
| |
| Total degradation in water : |
100 % of original compound found after 8 weeks in river water
(initial concentration 0.010 mg/l) (Verschueren 1983).
Biodegradation:
0% by BOD
period: 14d
substance: 100 mg/l
sludge: 30 mg/l
(MITI 1992)
|
| |
| Bioconcentration factor, fishes : |
| 10 |
10 - 13, Verschueren 1983 |
| 13 |
|
| 2720 |
2720 - 9060, 10w, Cyprinus carpio, conc 0.00005 mg/l, |
| 9060 |
|
| 2360 |
2360 - 12600, 10w, Cyprinus carpio, conc 0.000005 mg/l, |
| 12600 |
(lipid content 7.0 %) |
| 849 |
849 - 3250, 10w, Cyprinus carpio, conc 0.00005 mg/l, |
| 3250 |
|
| 1080 |
1080 - 7450, 10w, Cyprinus carpio, conc 0.000005 mg/l, |
| 7450 |
(lipid content 1.7 %), MITI 1992 |
| |
| Other information of bioaccumulation : |
Confirmed to be accumulated on a high level (Anon. 1987).
Bioconcentration factor (mollusca):
500 - 2780, mussels (Verschueren 1983).
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 3 |
orl-rat, Lewis & Sweet 1984 |
| 1.37 |
orl-mus, - " - |
| 3 |
orl-mky, - " - |
| |
| LD50 values to mammals in non-oral exposure , mg/kg : |
| 12 |
skn-rat, Lewis & Sweet 1984 |
| |
-- |
| 5 |
5 - 50, ukn-hmn |
| 50 |
Virtanen & Nuuja 1987 |
| |
-- |
| 7.5 |
7.5 - 18, ukn-rat |
| 18 |
|
| 29 |
ukn-mus, Virtanen & Nuuja 1987 |
| |
| Other information of mammals : |
LD50, in food, short-tailed shrew (Blarina brevicauda),
87 - 174 mg/kg (Virtanen & Nuuja 1987).
LDfr = 100 mg/kg/day, ALD 18 mg/kg, deer mouse (Peromyscus
maniculatus) (Virtanen & Nuuja 1987).
|
| |
| Health effects : |
0.2 mg/kg induces convulsions in human (Virtanen & Nuuja 1987). |
| |
| LD50 values to birds in oral exposure, mg/kg : |
| 1.8 |
orl-brd, Lewis & Sweet 1984 |
| 2 |
orl-bwd, - " - |
| |
-- |
| 2.37 |
orl-Agelaius phoeniceus |
| 2.37 |
2.37 - 3.16, orl-Sturnus vulgaris |
| 3.16 |
|
| 4.22 |
orl-Coturnix coturnix |
| 1.78 |
orl-Passer domesticus |
| 0.316 |
0.316 - 5.62, orl-Quiscalus quiscula |
| 5.62 |
|
| 5.62 |
orl-Columba livia |
| 1.5 |
orl-Falco sparverius |
| 2.1 |
orl-Myiopsitta monachus |
| |
Schafer et al. 1983 |
| |
| Effects on amphibia : |
LC50 0.0002 mg/l, 96hr, tadpoles of Rana hexadactyla (Khangarot
et al. 1985).
|
| |
| Effects on anthropods : |
LC50 0.00025 mg/l, 96hr, Pteronarcys californica (Sanders &
Cope 1968).
|
| |
| LC50 values to crustaceans, mg/l : |
| 0.039 |
48 hr, Daphnia magna, Gorbach & Knanf |
| |
1971 |
| |
-- |
| 0.0009 |
120hr, Gammarus fasciatus, Sanders 1972 |
| |
-- |
| 0.9 |
act, Daphnia pulex, Frear & Boyd 1967 |
| |
-- |
| 368 |
48hr, Daphnia pulex, Priester 1966 |
| |
-- |
| 0.35 |
act, Daphnia magna, Kenaga 1979 |
| |
| EC50 values to crustaceans, mg/l : |
| 20 |
20 - 352, 48hr, Daphnia pulex |
| 352 |
Shapiro 1979 |
| |
| LC50 values to fishes, mg/l : |
| 0.0048 |
72hr, Stizostedion lucioperca |
| 0.00006 |
72hr, Coregonus |
| 0.00007 |
Poelicia reticulata |
| |
72 hr, Salmo gairdneri, Wohlgemuth 1977 |
| |
-- |
| 0.00005 |
96 hr, Menidia beryllina, Eisler 1970a |
| |
-- |
| 0.0006 |
96hr, Lepomis macrochirus |
| |
Henderson et al. 1959 |
| |
-- |
| 0.0006 |
96hr, Salmo gairdneri, Katz 1961 |
| |
-- |
| 0.001 |
48hr, Carassius auratus |
| 0.0008 |
48hr, Cyprinus carpio |
| |
Hashimoto & Nishiuchi 1981 |
| |
-- |
| 0.0001 |
28 d, 91.1 %, Ictalurus melas |
| 0.034 |
96hr, Brachycentrus americanus |
| |
Anderson & Defoe 1980 |
| |
-- |
| 0.59 |
96hr, Pimephales promelas,Priester 1966 |
| |
-- |
| 0.0004 |
act, Lepomis macrochirus, Kenaga 1979 |
| 0.0086 |
act, Salmo gairdneri |
| 0.0011 |
act, Pimephales promelas |
| |
-- |
| 2.9 |
48hr, Oryzias latipes, MITI 1992 |
| |
| LOEC values to fishes, mg/l : |
| 0.0003 |
srv, chr, Cyprinodon variegatus |
| |
Ward & Parrish 1980 |
| |
-- |
| 0.0003 |
srv, grw, chr, Cyprinodon variegatus |
| |
Hansen et al. 1977a |
| |
-- |
| 0.0003 |
rpd, chr, flag fish, Hermanutz 1978 |
| |
| NOEC values to fishes, mg/l : |
| 0.0001 |
srv, grw, chr, Cyprinodon variegatus |
| |
Hansen et al. 1977a |
| |
-- |
| 0.0002 |
grw, chr, flag fish, Hermanutz 1978 |
| |
| Other information : |
Impurity of dieldrin.
|
References |
| 51 | Anderson, R.L. & DeFoe, D.L. 1980.
Toxicity and
bioaccumulation of endrin and methoxychlor in aquatic
invertebrates and fish.
Environ.
Poll. 22A: 111. |
| 2357 | Anon 1988.
Concentrations of industrial organic chemicals
measured in the environment: The influence of physico - chemical
properties, tonnage and use pattern.
Technical report no 29.
European chemical industry ecology & toxicology centre, ECETOC.
pp. 105. |
| 1848 | Anon. 1987a.
The list of the existing chemical substances tested
on biodegradability by microorganisms or bioaccumulation in
fish body by Chemicals Inspection & Testing Institute.
Ministry
of International Trade and Industry, MITI.
Japan. |
| 391 | Eisler, R. 1970a.
Acute toxicities of organochlorine and
organophosphorus insecticides to estuarine fishes.
Bureau of
Sport Fisheries and Wildlife Technical Paper 46, Government
Printing Office, Washington, D.C. |
| 447 | Frear, D.E.H. & Boyd, J.E. 1967.
Use of Daphnia magna for
microbioassay of pesticides, I.J.Econom.
Entomol. 60: 1228 -
1238. |
| 493 | Gorbach, S., Knauf, W. 1971.
Endosulfan and the environment.
Behaviour of residues of endosulfan in water and then effect
on organisms which live in water.
Schriftenr Ver Wasser Boden
Lufthyg.
Vol. 34: 85 - 93. |
| 534 | Hansen, D.J., Schimmel, S.D. & Forester, J. 1977a.
Endrin: Effects on entire life cycle of a saltwater fish
(sheepshead minnow).
J.
Ecol.
Environ.
Health 3: 721 - 733. |
| 550 | Hashimoto, Y. & Nishiuchi Y. 1981.
Establishment of
bioassay methods for the evaluation of acute toxicity of
pesticides to aquatic organisms.
J.
Pestic.
Sci.
(Jap.) 6: 257. |
| 570 | Henderson, C., Pickering, Q.H. & Tarzwell, C.M. 1959.
Relative
toxicity of ten chlorinated hydrocarbon insecticides to
four species of fish, Trans.
Amer.
Fish.
Soc. 88(1): 23 - 32. |
| 574 | Hermanutz, R.O. 1978.
Endrin and Malathion toxicity to
flagfish.
Arch.
Environ.
Contam.
Toxicol. 7: 159 - 168. |
| 697 | Katz, M. 1961.
Acute toxicity of some organic insecticides
to three species of salmonids and to the threespine
stickleback.
Trans.
Amer.
Fish.
Soc. 90(3): 264 - 268. |
| 705 | Kenaga, E.E. 1979.
Acute and chronic toxicity of 75
pesticides to various animal species.
Down to earth 35(2): 25 -
31. |
| 1767 | Khangarot, B.S., Sehgal, A. & Bhasin, E.K. 1985.
Man and
biosphere - Studies on the Sikkim Himalayas.
Part 5: Acute
toxicity of selected heavy metals on the tadpoles of Rana
hexadactyla.
Acta hydrochim. et hydrobiol. 13(2): 259 - 263. |
| 1768 | Khangarot, B.S., Sehgal, A. & Bhasin, M.K. 1985.
Man and
Biosphere - Studies on the Sikkim Himalayas.
Part 6: Toxicity
of selected pesticides to frog tadpole Rana hexadactyla
(Lesson).
Acta hydrochim. hydrobiol. 13(3): 391 - 394. |
| 1589 | Lewis, R.J. & Sweet, D.V. 1984.
Registry of toxic effects of
chemical substances.
National Institute for Occupational Safety
and Health.
No. 83-107-4. |
| 2777 | Mackay, D. 1982.
Correlation of bioconcentration factors.
Environ.
Sci.
Technol., 16(5): 274 - 278. |
| 3105 | MITI 1992.
Biodegradation and bioaccumulation data of existing
chemicals based on the CSCL Japan.
Compild under the Safety
Division Basic Industries Bureau Ministry of International
Trade & Industry, Japan.
Edited by Chemicals Inspection &
Testing Institute, Japan.
|
| 1144 | Priester.
L.E., Jr., 1966.
The accumulation and metabolism
of DDT, parathion, and endrin by aquatic food-chain organisms
source.
Dissertation Abstr. 27(5): 1661-B. |
| 1226 | Sanders, H.O. & Cope, O.B. 1968.
The relative toxicities
of several pesticides to naiads of three species of stoneflies.
Limnol.
Oceanogr. 13(1): 112 - 117. |
| 1223 | Sanders, H.O. 1972.
The toxicities of some insecticides to
four species of malocostracan crustacea.
Fish Pesticide
Res.
Lab.
Columbia, Mo., Bureau of Sport Fish and Wildlife. |
| 1743 | Schafer , E.W.Jr., Bowles, W.A.Jr., Hurlbut, J. 1983.
The acute
oral toxicity, repellency and hazard potential of 993 chemicals to
one or more species of wild and domestic birds.
Arch.
Environ.
Contam.
Toxicol. 12: 355 - 382. |
| 1468 | Verschueren, K. 1983.
Handbook of environmental data of
organic chemicals.
Van Nostrand Reinhold Co.
Inc., New York.
1310 s. |
| 1771 | Virtanen, M. & Nuuja, I. 1987.
Kemikaalien myrkyllisyys
luonnonvaraisille nisäkkäille.
Ympäristöministeriö.
Ympäristön-
ja luonnonsuojeluosasto.
Sarja D: 26. |
| 1509 | Ward, G.S. & Parrish, P.R. 1980.
Evaluation of early life stage
toxicity tests with embryos and juveniles of sheepshead
minnows.
In: Aquatic toxicology, ASTM STP 707.
Eaton, J.G.,
Parrish, P.R. & A.C.
Hendricks, A.C.
(eds.)
American Society
for Testing and Materials, Philadelphia. pp. 243 - 247. |
| 1560 | Wohlgemuth, E. 1977.
Toxicity of endrin to some species
of aquatic vertebrates, Prirodoved Pr.
Ustavu Cesk.
Akad.
Ved
Brne (Czech.) 11: 1. |
