| Chemical |
Polychlorinated triphenyls |
| CAS-number : |
12642-23-8 |
| |
| Synonyms : |
| PCT. |
| |
| Sumformula of the chemical : |
| C18H9Cl5 * Aroclor 5442 |
| |
| Uses : |
Aroclor 5442 is used in heat transfer, hydraulic fluids,
lubricants and insecticides.
|
| |
| Molecular weight : |
400
575 |
| |
| Log octanol/water coefficient, log Pow : |
| 5.5 |
Aroclor 5442, Anon. 1989 |
| |
| Ready biodegradability : |
Confirmed to be non-biodegradable (Anon. 1987). |
| |
| Other information of degradation : |
Less persistent against photo- and biodegradation than PCB
(Fawell & Hunt 1988).
|
| |
| Metabolism in mammals : |
Mouse and rat: strong accumulation in liver and in kidney,
heart and fat tissue, induction of the microsom cytocrom P-450
system in liver (Fawell & Hunt 1988).
|
| |
| Other information of bioaccumulation : |
Confirmed to be accumulated on a medium level (Anon. 1987).
Little laboratorium data available, but occurance in oysters,
fish and fish eating animals indicate bioaccumulation and
biomagnification in food chain (Addison et al. 1972).
Direct uptake and bioaccumulation in cod have been indicated
(Addison et al. 1972).
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 10600 |
orl-rat, Aroclor 5442, Sax & Lewis 1989 |
| |
| LD50 values to mammals in non-oral exposure , mg/kg : |
| 3160 |
skn-rbt, Aroclor 5442, Sax & Lewis 1989 |
| |
| Effects on physiology of mammals : |
Rhesus ape: 5000 mg/kg in food, 3 months, decreased weight,
hair fall down, oedema, changes in liver, injuries in the
mucous membrane of the stomach (Allen & Norback 1973).
|
| |
| Health effects : |
Moderately toxic by skin contact.
Mildly toxic by ingestion.
When heated to decomposition it emits toxic fumes of Cl- (Sax &
Lewis 1989).
|
| |
| Carcinogenicity : |
Mouse, 24 weeks study induced liver tumors (Shirai et al. 1978).
|
| |
| Effects on reproduction of birds : |
Chicken, 20 mg/kg with food, increased amount of deaths and
abnormal embryos (Cecil et al. 1974).
|
| |
| LC50 values to fishes, mg/l : |
| 50 |
>50, 96hr, Salmo clarki, |
| |
Mayer & Ellersieck 1986 |
References |
| 2893 | Addison, R.F., Fletcher, G.L., Ray, S. & Doane, J. 1972.
Analysis of a chlorinated terphenyl (Aroclor 5460) and its
deposition in tissues of cod (Gadus morhua).
Bull.
Environ.
Contam.
Toxicol. 8: 52. |
| 2894 | Allen, J.R. & Norback, D.H. 1973.
Polychlorinated biphenyl and
triphenyl induced gastric mucosal hyperplasia in primates.
Science 179: 498 - 499. |
| 1848 | Anon. 1987a.
The list of the existing chemical substances tested
on biodegradability by microorganisms or bioaccumulation in
fish body by Chemicals Inspection & Testing Institute.
Ministry
of International Trade and Industry, MITI.
Japan. |
| 2895 | Cecil, H.C., Bitman, J., Lillie, R.J. & Verret, J. 1974.
Embryotoxic and teratogenic effects in unhatched fertile eggs
from hens fed polychlorinated biphenyls (PCBs).
Bull.
Environ.
Contam.
Toxicol. 11: 489 - 495. |
| 2148 | Fawell, J.K. & Hunt, S. 1988.
Environmental toxicology -
organic pollutants.
Ellis Horwood Limited, Chichester. 440 s. |
| 2278 | Mayer, F.L. & Ellersieck, M.R. 1986.
Manual of acute toxicity:
interpretation and data base for 410 chemicals and 66 species
of freshwater animals.
U.S.
Fish and Wildlife Service.
Resource
Publication 160, Washington, D.C. |
| 2892 | Renberg, L., Sundström, G. & Reutergårdh, L. 1978.
Polychlorinated terphenyls (PCT) in Swedish white-tailed eagles
and in grey seals.
A preliminary study.
Chemosphere 6: 477 -
482. |
| 2578 | Reutergårdh, L. 1988.
Identification and distribution of
chlorinated organic pollutants in the environment.
PhD Thesis,
SNV Report 3465, Solna, 192 pp. |
| 2723 | Sax, N.I. & Lewis, Sr., R.J. 1989.
Dangerous properties of
industrial materials.
Seventh edition.
Van Nostrand Reinhold.
New York. |
| 2896 | Shirai, T., Miayata, Y., Nakanishi, K., Murasaki, G.I. & Ito, N.
1978.
Hepatocarcinogenicity of polychlorinated terphenyls in
ICR mice and its enhancement by hexachlorobenzene.
Cancer
Letters 4: 271 - 275. |
