| Chemical |
2-methoxyaniline |
| CAS-number : |
90-04-0 |
| |
| Synonyms : |
| 1-amino-2-methoxy-benzene |
| 2-aminoanisole |
| 2-aminomethoxybenzene |
| 2-methoxy-1-aminobenzene |
| o-aminoanisole |
| o-aminomethoxybenzene |
| o-anisidine |
| o-methoxyaniline |
| o-methoxyphenylamine |
| |
| Sumformula of the chemical : |
| C7H9NO |
| EINECS-number : |
| 2019631 |
| |
| Molecular weight : |
125.15 |
| |
| Spesicif gravity (water=1) : |
| 1.0923 |
at 20/4 °C |
| |
| Vapor density (air=1) : |
| 4.25 |
|
| |
| Conversion factor, 1 ppm in air=_mg/m3 : |
| 5.12 |
mg/m3 |
| |
| Conversion factor, 1 mg/m3 in air=_ppm : |
| 0.2 |
ppm |
| |
| Vapor pressure, mmHg : |
| 0.1 |
< 0.1 mmHg at 30 °C |
| |
-- |
| 0.018 |
0.02 - 0.05 hPa, at 20 °C |
| 0.038 |
EU RA Report 2002 |
| |
| Melting point, °C : |
| 6.2 |
|
| 5 |
MITI 1992 |
| |
| Boiling point, °C : |
| 224 |
|
| 225 |
MITI 1992 |
| |
| Log octanol/water coefficient, log Pow : |
| 0.95 |
|
| 1.18 |
measured, EU RA Report 2002 |
| |
| Volatilization : |
It can be concluded that o-anisidine is slightly to moderately
volatile from aqueous solution.
Estimated Henry's Law constant
is 0.03 Paxm3/mol (EU RA Report 2002).
|
| |
| Adsorption/desorption : |
From QSAR calculations a low potential for adsorption onto soil
or sediment is derived.
Soil adsorption coefficients can be
calculated from the log Kow of 1.18 using the QSAR equation for
anilines.
Calculated Koc-values were 11 and 38 l/kg,
respectively (EU RA Report 2002).
|
| |
| Photochemical degradation in air : |
Photooxidation half-life in air:
5.3hr - 0.53hr, based upon estimated reaction rate constant
with OH (Howard 1991).
For the photochemical reaction of the substance with airborne
OH radicals (5x10+5 moleculesxcm3) a degradation rate constant
of 9.4x10-11 cm3xmolecule-1xsec-1 was calculated with an
increment method resulting in a half-life of approximately 4.1
hours (EU RA Report 2002).
|
| |
| Photochemical degradation in water : |
Photooxidation half-life in water:
145d - 2.6d, scientific judgement based upon reaction rate
constants of the aromatic amine class with RO2 and OH
(Howard 1991).
|
| |
| Half-life in air, days : |
| 0.22 |
5.3hr - 0.53hr |
| 0.02 |
based upon estimated photooxidation half-lives in air. |
| |
Howard 1991 |
| |
| Half-life in soil, days : |
| 180 |
6mo - 4w, |
| 28 |
scientific judgement based upon estimated aqueous aerobic biodegradation half-life. |
| |
Howard 1991 |
| |
| Half-life in water, days : |
| 180 |
6mo - 2.6d, |
| 2.6 |
in surface water: high value based upon scientific judgement of estimated high aqueous biodegradation half-life. Low value based upon estimated low value for aqueous photooxidation, |
| 360 |
12mo - 8w, |
| 56 |
in ground water: scientific judgement based upon estimated aqueous aerobic biodegradation half-lives. |
| |
Howard 1991 |
| |
| Aerobic degradation in water : |
Aerobic half-life:
6mo - 4w, scientific judgement based upon aerobic aqueous
screening studies (Howard 1991).
|
| |
| Anaerobic degradation in water : |
Anaerobic half-life:
24mo - 8w, scientific judgement based upon estimated aerobic
aqueous biodegradation half-lives (Howard 1991).
|
| |
| Total degradation in soil : |
Decompositon period by a soil microflora: > 64 days
(Verschueren 1983).
|
| |
| Total degradation in water : |
Biodegradation:
40-69% by BOD (on the upward trend)
period: 14d
substance: 100mg/l
sludge: 30 mg/l
(MITI 1992)
|
| |
| Ready biodegradability : |
Confirmed to be biodegradable (Anon. 1987). |
| |
| Other information of degradation : |
There is evidence that ready biodegradation of o-anisidine only
takes place at certain favouring conditions most probably
depending on the inoculum used.
In the biodegradation test
conducted according to OECD guideline 301 F, o-anisidine was
found to be readily biodegradable.
Meeting the 10-day time
window criterion, 86% of the substance (initial concentration:
200 mg/l) was degraded within 28 days, as measured by
manometric respirometry.
The inoculum used was taken from a
municipal wastewater treatment plant.
The lag phase until
degradation started was 11 days.
Although the oxygen
consumption through nitrification was not considered in the
test report, the test result is indicative for ready
biodegradability.
In a Zahn-Wellens test (OECD 302 B) using
adapted sludge as inoculum, o-anisidine was removed by 98%
after 16 days.
The log phase was 11 days (EU RA Report 2002).
|
| |
| Other information of bioaccumulation : |
Based on the log Kow of 1.18 and QSAR equation a BCF of 2 can
be derived (EU RA Report 2002).
|
| |
| LD50 values to birds in oral exposure, mg/kg : |
| 750 |
orl-Agelaius phoeniceus |
| 1000 |
>1000, orl-Sturnus vulgaris |
| 422 |
orl-Coturnix coturnix |
| 421 |
orl-Passer domesticus |
| |
Schafer et al. 1983 |
| |
| Effects on wastewater treatment : |
Degradation by Aerobacter: 500 mg/l at 30 °C:
ring disruption: parent: 92 % in 120 hr
mutant: 100 % in 16 hr
(Verschueren 1983).
|
| |
| EC50 values to algae, mg/l : |
| 12 |
growth inhibition, Scenedesmus pannonicus |
| 21.1 |
72 hr, reduct in biomass increase, Selenastrum capricornutum |
| |
EU RA Report 2002 |
| |
| NOEC values to algae, mg/l : |
| 7.5 |
72 hr, Selenastrum capricornutum |
| |
EU RA Report 2002 |
| |
| LC50 values to crustaceans, mg/l : |
| 12 |
48 hr, Daphnia magna, EU RA Report 2002 |
| |
| EC50 values to crustaceans, mg/l : |
| 6.8 |
48 hr, Daphnia magna |
| 28.5 |
48 hr, Daphnia magna |
| 22.5 |
48 hr, Daphnia magna |
| 0.206 |
>0.206 mg/l, 21 d, repr. rate, Daphnia magna |
| |
EU RA Report 2002 |
| |
| NOEC values to crustaceans, mg/l : |
| 6.25 |
48 hr, Daphnia magna |
| 0.0549 |
21 d, repr. rate, Daphnia magna |
| |
EU RA Report 2002 |
| |
| LC50 values to fishes, mg/l : |
| 165 |
14 d, Poecilia reticulata |
| 100 |
>100 mg/l, 14 d, Oryzias latipes |
| 196 |
96 hr, Oryzias latipes |
| |
EU RA Report 2002 |
| |
| EC50 values to fishes, mg/l : |
| 18 |
14 d, behaviour, Poecilia reticulata |
| |
EU RA Report 2002 |
| |
| NOEC values to fishes, mg/l : |
| 25 |
14 d, Oryzias latipes, EU RA Report 2002 |
| |
| Other information of water organisms : |
For microorganisms one toxicity test is available, which was
conducted according to OECD 209 with activated sludge
originating from municipal sewage:
Activated sludge (effect: inhibition of respiration):
EC10= <58 mg/l (3 hours)
EC50 = 800 mg/l (3 hours)
EC80 = <1,000 mg/l (3 hours)
The effect concentrations are nominal values.
Because of the
short test duration, abiotic or biotic removal processes are
not expected to be of major importance (EU RA Report 2002).
|
References |
| 1848 | Anon. 1987a.
The list of the existing chemical substances tested
on biodegradability by microorganisms or bioaccumulation in
fish body by Chemicals Inspection & Testing Institute.
Ministry
of International Trade and Industry, MITI.
Japan. |
| 3355 | EU RA Report 2002.
Existing Substances: o-anisidine.
European
Union Risk Assessment Report (Vol 15).
Institute for Health and
consumer Protection.
European Chemicals Bureau.
European
Communities.
|
| 3120 | Howard, P.H., Boethling, R.S., Jarvis, W.F., Meylan, W.M. &
Michalenko, E.M., Handbook of Environmental Degradation Rates,
1991.
Lewis Publicers, Inc., Chelsea, Michigan, U.S.A.,
pp. 725.
|
| 3105 | MITI 1992.
Biodegradation and bioaccumulation data of existing
chemicals based on the CSCL Japan.
Compild under the Safety
Division Basic Industries Bureau Ministry of International
Trade & Industry, Japan.
Edited by Chemicals Inspection &
Testing Institute, Japan.
|
| 1743 | Schafer , E.W.Jr., Bowles, W.A.Jr., Hurlbut, J. 1983.
The acute
oral toxicity, repellency and hazard potential of 993 chemicals to
one or more species of wild and domestic birds.
Arch.
Environ.
Contam.
Toxicol. 12: 355 - 382. |
| 1468 | Verschueren, K. 1983.
Handbook of environmental data of
organic chemicals.
Van Nostrand Reinhold Co.
Inc., New York.
1310 s. |
