| Chemical |
Cyclohexane |
| CAS-number : |
110-82-7 |
| |
| Synonyms : |
| heksahydrobentseeni |
| hexahydrobenzene |
| Sykloheksaani |
| |
| Sumformula of the chemical : |
|
C6H12 |
| EINECS-number : |
| 2038062 |
| |
| State and appearance : |
Colorless, mobile liquid.
|
| |
| Odor : |
Odour Index (O.I.) at 20 °C = 203000
In water: reduction of amenities: Threshold Odour Concentration:
(T.O.C.) = 0.02 mg/l
(Verschueren 1983)
|
| |
| Molecular weight : |
84.16 |
| |
| Spesicif gravity (water=1) : |
| 0.779 |
|
| |
| Conversion factor, 1 ppm in air=_mg/m3 : |
| 3.49 |
mg/m3, Verschueren 1983 |
| |
| Conversion factor, 1 mg/m3 in air=_ppm : |
| 0.29 |
ppm, Verschueren 1983 |
| |
| Vapor pressure, mmHg : |
| 77 |
at 20 °C, Verschueren 1983 |
| |
| Water solubility, mg/l : |
| 100 |
< 100 |
| 55 |
at 20 °C |
| 45 |
at 15 °C |
| |
| Melting point, °C : |
| 6.3 |
|
| 6.5 |
MITI 1992 |
| |
| Boiling point, °C : |
| 80.7 |
|
| 80.75 |
MITI 1992 |
| |
| Log octanol/water coefficient, log Pow : |
| 3.44 |
Sangster 1989 |
| |
| Henry's law constant, Pa x m3/mol : |
| 19530 |
calc. Yaws et al. 1991 |
| |
| Volatilization : |
Relative volatility (nBuAc=1) = 7.36
|
| |
| Photochemical degradation in air : |
Photooxidation half-life:
3.6d - 8.7hr, based upon measured rate data for the vapor phase
reaction with hydroxyl radicals in air (Howard 1991).
|
| |
| Half-life in air, days : |
| 3.6 |
3.6d - 8.7hr, |
| 0.36 |
based upon photooxidation half-life in air. |
| |
Howard 1991 |
| |
| Half-life in soil, days : |
| 180 |
6mo - 4we, |
| 28 |
scientific judgement based upon unacclimated grab sample of aerobic soil (high t1/2) and aerobic aqueous screening test data. |
| |
Howard 1991 |
| |
| Half-life in water, days : |
| 180 |
6mo - 4we, |
| 28 |
in surface water, scientific judgement based upon estimated unacclimated aqueous aerobic biodegradation half-life. |
| 360 |
12mo - 8we, |
| 56 |
scientific judgement based upon unacclimated aqueous aerobic biodegradation half-life. |
| |
Howard 1991 |
| |
| Aerobic degradation in water : |
Microbial degradation of cyclohexane:
XH2 --> X NADP+ <---> NADPH
Cyclohexane -------> cyclohexanol <-------------> cyclohexanone
O2 --> H2O
NADPH --> NADP+ H2O -->
-------------> 1-oxa-2-oxocycloheptane -------->
NADPH <-- NADP+ NADP+ --> NADPH
6-hydroxyhexanoate -------------> 6-oxohexanoate ------------>
adipic acid ---> ---> Acetyl-CoA + Succinyl-CoA
(Verschueren 1983)
Aerobic half-life:
6mo - 4we, scientific judgement based upon unacclimated grab
sample of aerobic soil (high t1/2) and aerobic aqueous
screening test data (Howard 1991).
|
| |
| Anaerobic degradation in water : |
Anaerobic half-life:
24mo - 16we, scientific judgement based upon estimated
unacclimated aqueous aerobic biodegradation half-life (Howard
1991).
|
| |
| Total degradation in water : |
Biodegradation:
0.6% by BOD
period: 14d
substance: 100 mg/l
sludge: 30 mg/l
(MITI 1992)
|
| |
| Bioconcentration factor, fishes : |
| 31 |
31 - 102, 8w, Cyprinus carpio, conc 0.1 mg/l, |
| 102 |
|
| 37 |
37 - 129, 8w, Cyprinus carpio, conc 0.01 mg/l, |
| 129 |
MITI 1992 |
| |
| Other information of bioaccumulation : |
Confirmed to be non-accumulative or low accumulative (Anon.
1987).
|
| |
| LD50 values to mammals in oral exposure, mg/kg : |
| 1297 |
orl-mus |
| |
| Other information of mammals : |
Mouse: inhalation: LC50: -+18000 ppm, 1 hr
rabbit: inhalation: no effect level: 786 ppm, 10 weeks
monkey: inhalation: no effect level: 1243 ppm, 6hr/day, 50days |
| |
| Health effects : |
Man: irritating to the eyes and mucous membranes: 300 ppm
(Patty 1967)
|
| |
| Mutagenicity : |
Mutagenicity in the Salmonella test: none
<0.006 revertant colonies/nmol
<70 revertant colonies at 1000 mikro-g/plate
(McCann et al. 1975)
|
| |
| LC50 values to fishes, mg/l : |
| 93 |
96hr, Pimephales promelas |
| |
Vincent et al. 1976 |
| |
-- |
| 32 |
96hr, Pimephales promelas |
| 34 |
96hr, Pimephales promelas |
| |
Pickering & Henderson 1966 |
| |
-- |
| 93 |
96hr, Lake Superior, Pimephales promelas |
| 117 |
96hr, reconst. water,Pimephales promelas |
| |
Mattson et al. 1976 |
| |
-- |
| 9 |
48hr, Oryzias latipes, MITI 1992 |
| |
-- |
| 4.53 |
96 hr, Pimephales promelas, Geiger et al. 1990 |
| |
| EC50 values to fishes, mg/l : |
| 4.53 |
96 hr, mbt, Pimephales promelas, Geiger et al. 1990 |
| |
| Effects on reproduction of water organisms : |
Threshold conc. of cell multiplication inhibition of the
protozoa Uronema parduczi Chatton-Lwoff: >50 mg/l
(Bringmann & Kühn 1980b)
|
| |
| Other information of water organisms : |
Incubation with natural flora in the groundwater-in presence of
the other components of high-octane gasoline (100 mikro-l/l)
(Jamison et al. 1976)
Mussel larvae (Mytilus edulis): 10-20 % increase of growth rate
at 1 to 100 ppm (Verschueren 1983).
Young Coho salmon: no significant mortalities up to 100 ppm
after 96 hrs in artificial sea water at 8 °C (Verschueren
1983).
|
References |
| 1848 | Anon. 1987a.
The list of the existing chemical substances tested
on biodegradability by microorganisms or bioaccumulation in
fish body by Chemicals Inspection & Testing Institute.
Ministry
of International Trade and Industry, MITI.
Japan. |
| 189 | Bringmann, G. & Kühn, R. 1980b.
Bestimmung der biologischen
Schadwirkung wassergefahrdender Stoffe gegen Protozoen.
II.
Bakterienfressende Ciliaten, Z.
Wasser/Abwasser Forsch. 1: 26 -
31. |
| 3297 | Geiger, D.
L. et al. 1990.
Acute toxicities of organic
chemicals to fathead minnows (Pimephales promelas) Vol 5.
Center for Lake Superior Environmental Studies, University of
Winsconsin-Superior, Superior, Winconsin, U.S.A. 332.
|
| 3120 | Howard, P.H., Boethling, R.S., Jarvis, W.F., Meylan, W.M. &
Michalenko, E.M., Handbook of Environmental Degradation Rates,
1991.
Lewis Publicers, Inc., Chelsea, Michigan, U.S.A.,
pp. 725.
|
| 1873 | Jamison.
V.W., Raymond, R.L. & Hudson, J.O. 1976.
Biodegradation of high-octane gasoline.
In: J.M.
Sharpley and
A.M.
Kaplan (eds.).
Proceedings of the Third International
Biodegradation Symposium.
Applied Science Publishers, pp. 187 -
196. |
| 1646 | Mattson, V.R., Arthur, J.W. & Walbridge, C.T. 1976.
Acute
toxicity of selected organic compounds (resorcinol and
6-methylquinoline) to Daphnia magna.
Bull. of Env.
Cont. & Tox.
27(1). |
| 912 | McCann, J. et al. 1975.
Detection of carcinogens as
mutagens in the Salmonella/microsome test: Assay of 300
chemicals, Proc.
Nat.
Acad.
Sci.
USA, 72(12): 5135-5139 Medical
Sciences, Dec. |
| 3105 | MITI 1992.
Biodegradation and bioaccumulation data of existing
chemicals based on the CSCL Japan.
Compild under the Safety
Division Basic Industries Bureau Ministry of International
Trade & Industry, Japan.
Edited by Chemicals Inspection &
Testing Institute, Japan.
|
| 1644 | Patty, F.A. 1967.
Industrial hygiene and toxicology.
Vol 2.
Interscience Publishers. |
| 1129 | Pickering, Q.H. & Henderson, C. 1966.
Acute toxicity of some
important petrochemicals to fish.
J.
Water Pollut.
Control
Feder. 38: 1419 - 1429. |
| 3104 | Sangster, J. 1989.
Octanol-water partition coefficients of
simple organic compounds.
J.
Phys.
Chem.
Ref.
Data, Vol 18, No.
3: 1111 - 1229. |
| 1468 | Verschueren, K. 1983.
Handbook of environmental data of
organic chemicals.
Van Nostrand Reinhold Co.
Inc., New York.
1310 s. |
| 1474 | Vincent, R.M., Arthur, J.W. & Walbridge, C.R. 1976.
Acute
toxicity of selected organic compounds to fathead minnows.
EPA-600/3-76-097. |
| 3030 | Yaws, C., Yang, H-C. & Pan, X. 1991.
Henry's law constants for
362 organic compounds in water.
Chemical Engineering.
November.
p 179 - 185. |
